Ziekte van Addisons. Hyperpigmentatie die een accentuering van normale pigmentatie voorstelt van de hand van een patiënt met de ziekte van Addisons (links). Ter vergelijking, de hand van een normaal individu, gematcht voor etnische pigmentatie, wordt getoond aan de rechterkant.
Drugsgeïnduceerde pigmentatie: amiodaron Een opvallende leigrijze pigmentatie in een fotodistributie van het gelaat. De blauwe kleur (ceruloderma) is te wijten aan de afzetting van melanine en lipofuscine in macrofagen en endotheelcellen in de dermis. De pigmentatie is omkeerbaar, maar het kan wel een jaar of langer duren voordat het volledig is verdwenen. Bij deze patiënt duurde het 33 maanden voordat de cerulodermie was verdwenen.
Het echte, werkende veneuze systeem voor de benen ligt dieper in het been. Dit is goed nieuws, want het betekent dat als de oppervlakkige aderen spataderen worden, ze kunnen worden verwijderd of vernietigd zonder de circulatie naar het been te ruïneren.
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